Macrocyclics

FEATURED PRODUCT
p-SCN-Bn-PCTA
Of major interest in the advancement of positron emission tomography (PET) are new bifunctional ligands designed specifically for Cu-64 and Ga-68. In the case of Cu-64, typical ligand systems known to form good complexes require conditions which are too harsh for labeling of monoclonal antibody conjugates. Recent reports from our collaborative research program with Nordion now describe a new bifunctional ligand, p-SCN-Bn-PCTA (B-405), which exhibits rapid radiolabeling (95%) with Cu-64 under mild conditions that are compatible with MAB’s. In addition, B-405 performs equally well with Ga-68 making this ligand an outstanding choice for a broad spectrum of molecular imaging applications.

cGMP Services
Macrocyclics introduced its cGMP manufacturing services in 2005. Our quality system is designed specifically for the manufacture of APIs to be used in clinical trials. These services can be applied to our in-house line of catalog products or custom syntheses for particular client needs.
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Consulting Services
The staff at Macrocyclics has an international reputation in the field of medical chelation chemistry. Areas of expertise include the design of bifunctional ligands for radiopharmaceutical applications, magnetic resonance imaging contrast agents, and optical imaging probes based on metal chelates.
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