Macrocyclics specializes in custom synthesis solutions to advance your small molecule programs. Our expertise supports the development of new linker mechanisms, drug conjugates, and imaging precursors, facilitating innovation and execution in your research
our StrengthYour Advantage
Custom synthesis requires exceptional analytical method development to optimize yield, purity, and scalability. At Macrocyclics:
- ⌬ HPLC is our preferred method for purity assessment and is applied throughout the synthetic process.
- ⌬ Through in-process sampling, we monitor impurity development and employ optimized strategies to control and reduce them. This involves adjustments in reaction conditions, extraction solvents, chromatographic purifications, and isolation techniques.
Our team of chemists is committed to understanding and meeting your project requirements, ensuring efficiency from design to delivery.
- ⌬ Project managers will work with you to understand the scope and objectives of the program, then develop a quote tailored to the specific needs of your program.
- ⌬ A dedicated project team provides consistent communication from start to finish
- ⌬ All manufacturing occurs in-house at our Plano, Texas facility.
Core Capabilities
Modification to Chelator/Linker
- ⌬ Maleimides, amino acids, PEG(n), and Click-chemistry products
- ⌬ Stable isotope complexes and reference standards
- ⌬ Novel ligands, dual-chelators, and multi-functional linkers
Small Molecule Conjugates
- ⌬ Polypeptides and cyclic peptides
- ⌬ Biotinylation and fluorescent labeling for advanced functionalization
Complex Intermediates
- ⌬ Precursors for PET tracers
- ⌬ API building blocks and synthetic intermediates
- ⌬ Prosthetic groups (including 211-At & 125-I labeling)
Kilo-Scale Manufacturing
